ESense-Lab Ltd (ASX: ESE) is an Israeli-based R&D technology company. ESE has commercialised technology to reverse engineer the “terpene profile” of rare or valuable plants using natural alternatives. Terpenes are a phytochemical (natural compound) that define the scent and flavour of plants, forming a unique profile when combined.
Initially, eSense-Lab will focus on terpene profiles for cannabis used in e-liquids. Reconstructed profiles exclude ‘cannabinoids’ and are therefore not subject to the same regulations as cannabis.
The company intend to target other plants and spices used across a wide range of applications (cosmetics, household goods, food and beverages).
|Listing Date||14th February|
|Market Cap.||$12m (approx.)|
|Lead Manager||Otsana Capital|
The primary market for ESE’s technology is e-cigarettes and e-liquids. Patented in 2003, e-cigarettes have experienced prolific growth. Global sales have grown from approximately US$500m in 2009, to US$3bn per year in 2013, and then US$7.5bn in 2015.
In the US alone, the e-cigarette market is anticipated to surpass $10bn in 2017. Meanwhile, e-liquid products accounted for €1.34bn in sales throughout Europe, Africa and the Middle-East in 2015.
Looking ahead, Europe’s e-liquid market is expected to grow at a double-digit CAGR to reach $11bn by 2025. Globally, e-cigarettes are expected to surpass $47bn in sales by 2025, with non-tobacco, flavoured products increasingly favoured. E-cigarettes have grown in prominence due to:
- A perception they are “less harmful than regular cigarettes”
- As means to reduce consumption of regular cigarettes
- The ability to smoke e-cigarettes in non-smoking areas
- A belief that e-cigarette vapour is “less bothersome” to bystanders
Consumption of cannabis through e-cigarettes is believed to be low due to cannabinoids being “poorly soluble in e-liquids”. The US retail market for cannabis is forecast to grow from US$4.0-5.5bn in 2017, up to US$11bn by 2020.
Total recreational demand for cannabis in the US is estimated between US$40-45bn, exceeding sales for markets like wine, organic food, and craft beer.
ESense-Lab will target markets for alcohol, beverages, edibles, household goods, cosmetics, pharmaceuticals, therapeutics, topical creams and essential oils – globally, essential oils are “growing at over 10% annually” and “estimated at US$6 billion in 2015”.
Offer Details and Use of Funds
ESE is raising $3.5m via 17.5m CDIs at $0.20 – each equivalent to one share. The company will use the funds to: enable commercial production; conduct further R&D into other terpene profiles and products; develop the business and implement its strategy by securing customers, distributors and licensees.
Products and Production
ESense-Lab develop reconstructed terpene profiles using 100% natural and organic materials. These mirror the chemical composition and qualities of a target plant with 99.9% accuracy.
The business’ technology has been scientifically “validated” as meeting the necessary standards for phytochemical profiling. Existing competitors process the plant itself or include significantly less terpenes, thus eSense-Lab’s technology has several benefits:
- Significantly reduced costs (compared with US$200k-700k per litre)
- Reduced environmental impact
- Permits scalability
- Regulatory flexibility by omitting certain terpenes without detriment (e.g. cannabinoids)
- 100% consistency (unlike raw plant extracts)
- Detection accuracy of >0.001% (>0.1% for chemical profiling)
- Standardised nature lends itself towards use in pharmaceutical and medical applications
- Individual compound concentrations can be tailored for specific users
- Applicable for a variety of applications with modest development time
ESE has developed terpene profiles for 10 types of cannabis plant, with another 20 in progress. The business has lodged a patent application for ‘mixtures of phytochemicals’. The reverse engineering process can be simplified as follows:
- Deformulation: Unique for each plant. Chemical, DNA, RNA and protein components are extracted through a variety of techniques (grinding, microwaved, pressurisation, etc.)
- Preformulation: Analysis of the target plant’s chemical compounds to characterise its properties. Parameters are developed as a QC measure to guide formulation.
- Formulation: Software is used to model the interaction between chemical compounds.
- Reconstruction: Individual base terpenes are acquired from US and European producers. They are refined, validated and combined to form a terpene profile ready for distribution.
Initial orders will rely on the services of Herbal Remedies Laboratories Ltd – a leading Israeli company involved with pharmaceuticals. With preformulation and formulation completed in-house, ESE are afforded control, efficiency, reliability and quality. Production is made-to-order, with capacity for over 100 litres per day from a single plant.
In the future, ESE intend to manufacture in-house. This includes the option to independently or jointly develop its own products that include reconstructed terpene profiles.
Sales, Distribution & Strategy
ESE has secured its first commercial order for cannabis terpene profiles, from Allor Vaporizers – a US-based electronic vaporizer business. The order, valued at US$470,000 (approx. US$20,000 per litre), is expected to be fulfilled by April 2017.
The business has outlined its growth strategy post-listing:
- Phase One (Lab Development):
- Purchase lab equipment for in-house production;
- Target potential customers, distributors, sublicensees in the B2B market;
- Establish online distribution platform;
- File cannabis research licenses;
- Undertake market research for other terpene profile applications
- Phase Two (Production Ramp Up):
- Increase production and sales of e-liquid terpene profiles to end users and distributors
- Phase Three (Edibles and beverages):
- Increase production and marketing to an industrial level, targeting applications such as soft drinks, energy drinks, edible products, alcohol
- Phase Four (Cosmetics and household products):
- As part of a joint venture, target cosmetic companies and applications to enhance the brand’s position
- Pursue partners for toiletries, fragrances, laundry products
- Phase Five (Pharmaceuticals):
- Undertake intensive research;
- Collaborate ,or form a joint venture with a pharmaceutical business, to develop products including cannabis terpene profiles (subject to regulatory approval, testing)
(excl. options + rights)
|Dr. Brendan de Kauwe||Chairman and Non-Executive Director||Director of Otsana Capital; significant IPO/RTO experience. Extensive tech, science and biomedical background. Various Director roles with ASX companies including RAC & OOK.||$85,000 p.a.|
|Mr Haim Cohen||CEO & Director||Managerial experience with public & private businesses across real estate, transport comms, HR and information systems.||US$150,000 p.a.|
|Mr IIan Saad||Non-Executive Director||Distribution experience concerning IT, semiconductors & automation. CEO of a leading IT distributor in Israel.||$50,000 p.a.|
|Mr Eran Gilboa||Non-Executive Director||Various roles as CFO within tech, real estate, finance & media. Experience with M&A activity.||$50,000 p.a.|
|Ms Galit Assaf||Non-Executive Director||Various managerial and director roles with Israeli businesses and government, including CFO and acting/deputy CEO.||$50,000 p.a.|
|Mr Quentin Megson||Non-Executive Director||25 years’ experience within Australia’s finance & management industry. Various ASX roles (CFO, GM HR, GM operations).||$50,000 p.a.|
Several agreements are also in place with key staff for their technical, scientific and advisory roles – namely: Dr Yaron Penn; Dr Mira Carmeli-Weissberg; Prof. Zvi Vogel (refer: Prospectus 7.4).
The capital structure of the business is illustrated in Figure 3. ESE nominate 63.63% of issued shares to be escrowed (undiluted basis), or 83.14% (fully diluted basis). Options and performance rights are expected to be escrowed 24 months from official quotation.
Performance rights may be executed in accordance with various milestones such as trading price, distribution contract value, and cumulative revenue (refer: Prospectus 9.4). Otsana’s options may be exercised at $0.25, with a 36 month expiry from issue.
In November, ESE agreed to issue 1,110,689 incentive options. Directors were assigned 472,000 options and exercised them at NIS 0.01. The remaining options (638,689) were issued to Professor Zvi Vogel with the same exercise price.
ESense-Lab signed a convertible loan for $1m with 27 investors, convertible into CDIs at $0.10.
Figures 5 & 6 depict the director holdings and substantial shareholders.
Incororated in April 2016, the company has a limited operating history. Since then, eSense-Lab recorded a loss of $238,000. The Directors have concluded they are currently unable to forecast earnings.
Company specific risks include:
- Limited Operations: ESE has yet to commercialise production
- Customers: Sufficient product demand has yet to be proven. Misperceptions around extracts vs reconstruction, and removing certain terpenes, could be a barrier. Contract cancellations could force alternative arrangements.
- New Markets: High cost to enter new markets
- Production Issues: Technology risks or process misunderstandings could cause delays
- Intellectual Property: Rejected patent application; failure to protect IP; IP infringement(s)
- Technology: IT or lab failures have the potential to materially impact ESE. New technology could impact revenue.
- Regulations: New or amended regulations could force eSense-Lab to revise its strategy. It is not guaranteed ESE will attain necessary approval(s), or pass necessary tests for future markets.
- Third Parties: Failures or contractual grievances with suppliers and/or manufacturers could disrupt operations
- Key Personnel: The loss of key personnel could disrupt operational momentum
- Israeli-based Business: Political, economic and military factors. Differences in corporate law.
- Liability: The brand and business may be impacted by litigation or product issues
- Liquidity & Forex: A high portion of ESE’s shares are locked in escrow. The business operates across numerous jurisdictions with different currency.
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